Fig. 2.

Physical Developmental Milestones and Reflex Development in Pups Exposed to 100 μg/kg Lipopolysaccharide (LPS) or Saline at Gestational Age 15–16 (Mean of 6 Litters Per Treatment). (A) Weight gain: assessed at birth and during days P6–P16; (B, C) time of eye and ear canal opening: monitored from days P13 to P17; and (D) forelimb grasp reflex: the reflex was delayed for 1 d in LPS-treated pups comparing to saline controls (*P < .05). In (B–D), data shown as percentage of pups per litter fully performed the task. Values are expressed as mean ± standard error of the mean. (*P < .05 LPS- vs saline-treated offspring).