Table 1.

Synaptosome Proteins Altered by Subchronic MK-801 Treatment

	Accession no. NCBI	Gene Name	Mascot Score	Theoretical Molecular Weight (Da)/PI	7-Day Group		21-Day Group		ANOVA	Presynaptic Proteins	Postsynaptic Proteins	Synaptic Complex
					FC	P Value	FC	P value
1	gi|114326546	Pgam1	119	28813.9/6.67	−1.36	.00001	1.03	.674	0.00002	√22	√21
2	gi|157824168	Hdhd3	89	27776.2/6.5	1.17	.000031	1.04	.2	0.00011
3	gi|55741424	Ndufv1	248	50698.6/8.37	−1.21	.000034	−1.06	.151	0.00017	√22
4	gi|18093102	Dnm1	351	95867.2/6.32	1.2	.000097	1.18	.00022	0.00017	√22–25	√21	SV25
5	gi|58865372	Hsph1	102	96357.4/5.4	1.12	.0006	1.11	.00666	0.00064		√21
6	gi|158187544	Pygb	442	96676.5/6.31	1.14	.018	1	.91	0.001	√25	√21	SV25
7	gi|201066380	Fscn1	239	54456.9/6.29	−1.03	.24	−1.09	.0022	0.0012		√21, PSD-95–associated26
8	gi|205829956	Napb	275	33448.5/5.32	1.07	.033	−1.05	.114	0.0013	√23,25	√21	SV25
9	gi|25742568	Crmp4	99	61928/6.04	1.18	.00042	1.07	.137	0.00178	√23
10	gi|8393962	Pitpna	278	31887.1/5.97	1.1	.0031	−1.01	.772	0.00223
11	gi|195927000	Dlst	113	48868.4/8.9	−1.26	.0028	−1.2	.0084	0.00226		√21
12	gi|56961640	Pcmt1	136	24625.7/7.14	1.14	.00055	1.09	.0368	0.00252
13	gi|6714522	Crmp5	85	61356.1/6.5	1.16	.0026	1.09	.035	0.00486		√21
14	gi|19173766	Lonp1	204	105726.2/6.17	−1.18	.005	−1.12	.0026	0.0052
15	gi|78365255	Dlat	180	67123.4/8.76	−1.14	.0096	−1.04	.334	0.0065	√22,25	√21	SV25, MASC21, NRC27
16	gi|17105370	Atp6v1b2	245	56514.9/5.57	1.14	.006	1.04	.362	0.007	√22–25	√21	SV25
17	gi|16758840	Crym	212	33533.1/5.34	1.11	.022	1.01	.585	0.0071		PSD-95–associated26
18	gi|60678254	Ckmt1	111	46932.2/8.58	−1.09	.075	−1.14	1.0 × 10−5	0.0073	√22,25	√21	SV25
19	gi|157817227	Ndufs3	205	28028.2/6.31	−1.07	.039	−1.15	.00046	0.0079	√22,24	√21
20	gi|13928850	Phgdh	92	56457.2/6.28	1.12	.11	−1.05	.401	0.0081
21	gi|18034791	Napa	120	33171.2/5.3	1.07	.071	−1.06	.169	0.0083	√22,23	√21
22	gi|58219062	Cndp2	193	52659.6/5.43	1.06	.12	−1.06	.188	0.009
23	gi|26023949	Eno2	173	47110.9/5.03	1.2	.0078	1.14	.0112	0.0098	√23	√21
24	gi|6978593	Camk2a	78	54080.6/6.61	−1.09	.042	−1.13	.0084	0.011	√22–25	√21, PSD-95-associated26	SV25, MASC21, NRC27
25	gi|15100179	Mdh1	178	36460.1/6.15	1.1	.014	1.02	.694	0.0119	√23
26	gi|4557469	Ap2b1	208	104486/5.22	1.11	.012	1.06	.0459	0.0128	√22–25	√21	SV25, MASC21
27	gi|8394152	Gnao1	337	40042.9/5.34	1.07	.11	−1.05	.203	0.0129	√22,23,25	√21, PSD-95-associated26	SV25, MASC21
28	gi|40254595	Crmp2	328	62238.6/5.95	1.1	.041	1.08	.057	0.0135	√22–24	√21	MASC21
29	gi|160406738	Sh3gl2	218	39874/5.26	1.11	.035	1	.968	0.0136	√22,24
30	gi|51948476	Uqcrc1	148	52815.4/5.57	−1.11	.011	−1.09	.0067	0.0067		√21
31	gi|157819689	Sept8	287	49825.2/5.68	1.12	016	−1.02	.693	0.0032	√24	√21
32	gi|53850628	Ndufs1	546	79361.6/5.65	−1.09	.18	−1.15	.0011	0.0156		√21
33	gi|6980978	Gpd2	236	80921.3/6.18	1.02	.75	−1.12	.0158	0.0168		√21
34	gi|8393296	Eef2	226	95222.9/6.41	1.09	.011	1.01	.759	0.017	√22,24	√21
35	gi|203476	Ckb	242	40598.3/5.32	−1.06	.29	1.09	.196	0.0176	√22,24,25	√21	SV25
36	gi|148747414	Gda	286	50868.7/5.48	−1.13	.034	−1.03	.579	0.0179		PSD-95–associated26
37	gi|38181948	Glul	268	42241.3/6.47	1.18	.0056	1.03	.736	0.0179	√23	√21, PSD-95–associated26	MASC21
38	gi|18426858	Sdha	251	71569.7/6.75	−1.01	.82	−1.1	.0108	0.0188		PSD-95–associated26
39	gi|158186661	Crmp3	191	61940.6/6.51	1.05	.28	−1.08	.029	0.0198	√25	√21	SV25
40	gi|40254781	Gdi2	286	50504.7/5.93	1.09	.047	−1.03	.544	0.02
41	gi|40786469	Dld	64	54004.1/7.96	−1.1	.082	−1.11	.0079	0.0232		√21
42	gi|109505678	LOC729708	84	26919.8/6.45	1.09	.016	1.1	.01	0.0251
43	gi|22122615	Actr1b	111	42254.7/5.98	1.06	.012	1.01	.638	0.0251
44	gi|1374715	Atp5b	267	51170.6/4.920	−1.14	.05	1.02	.645	0.0281	√22,23	√21, PSD-95–associated26
45	gi|158749584	Sucla2	160	50274.1/7.57	−1.12	.024	−1.1	.0076	0.0287		√21, PSD-95–associated26
46	gi|16758446	Idh3a	64	39588/6.47	−1.08	.052	−1.1	.0003	0.0301	√22	√21
47	gi|109468279	Mettl8	67	52417.4/8.94	−1.14	.066	−1.19	.0009	0.0303
48	gi|149015801	Rbmx	76	27913.1/10.03	−1.1	.1	−1.14	.00243	0.046
49	gi|6980956	Glud1	210	61377.3/8.05	−1.08	.342	−1.17	.00021	0.032	√22,25	√21	SV25

Note: NCBI, National Center for Biotechnology Information; FC, fold change; PSD-95, postsynaptic density-95; SV, synaptic vesicle; NRC, NMDA receptor complex; MASC, combines proteins found in both NRC and membrane-associated guanylate kinase (MAGUK) complex.²¹