Table 3.

Ingenuity Pathway Analysis of Differentially Expressed Proteins. (a) Top Networks and Associated Functions Involved in the Effect of MK-801. (b) Top Canonical Signaling Pathways Involved in the Effect of MK-801

(a) Top Networks
	Associated network functions			Score
21-Day treatment	Cell morphology, cell-to-cell signaling and interaction, nervous system development and function			28
	Carbohydrate metabolism			2
	Endocrine system disorders, hematological disease, metabolic disease			2
	Cancer, tumor morphology, cell death			2
7-Day treatment	Cell morphology, cell-to-cell signaling and interaction, nervous system development and function			21
	Cellular function and maintenance, lipid metabolism, neurological disease			7
	Carbohydrate metabolism			2
	Cancer, cell cycle, cell morphology			2
	Amino acid metabolism, molecular transport, small molecular biochemistry			2
(b) Top Canonical Pathways
7-Day treatment			21-Day treatment
	P value	Ratio		P value	Ratio
Citrate cycle	2.56 × 10−5	3/31 (0.097)	Citrate cycle	2.84 × 10−10	6/31 (0.194)
Glycolysis/gluconeogenesis	2.74 × 10−5	4/100 (0.04)	Mitochondrial dysfunction	2.07 × 10−8	6/132 (0.045)
Oxidative phosphorylation	1.97 × 10−4	4/151 (0.026)	Oxidative phosphorylation	3.76 × 10−5	4/151 (0.026)
Semaphorin signaling in neurons	2.09 × 10−4	3/55 (0.055)	Glycolysis/gluconeogenesis	2.1 × 10−4	3/100 (0.03)