Table 1.
Patient demographic, clinical and laboratory features including ex vivo parasite development in preparation for static binding assays
| Patient details | |||||
|---|---|---|---|---|---|
| Study reference | P0002 | P0006 | P0009 | P0010 | P0011 |
| Age | 16 | 47 | 28 | 27 | 37 |
| Sex | M | F | M | M | M |
| % Parasitaemia | 0.4 | 0.8 | 7 | 0.8 | 1.3 |
| Fever duration (days) | 7 | 5 | 6 | 5 | 4 |
| Axillary Temp°C | 37.5 | 38.5 | 39.2 | 38.7 | 38 |
| Mean Art BP mmHg | 79 | 96 | 70 | 86 | 77 |
| Pulse per min | 62 | 96 | 96 | 103 | 94 |
| Haemoglobin g/dL | 13.4 | 13.2 | 12.3 | 14.1 | 12.8 |
| Platelets/uL | 93,000 | 106,000 | 19,000 | 39,000 | 65,000 |
| White cells/uL | 6600 | 6700 | 6900 | 7500 | 4600 |
| Sodium mmol/L | 133 | 131 | 120 | 132 | 131 |
| Potassium mmol/L | 3.7 | 4.9 | 3.6 | 3.3 | 3.9 |
| Chloride mmol/L | 100 | 99 | 92 | 101 | 100 |
| Total bilirubin umol/L | 20.6 | 15.7 | 38.4 | 9.7 | 48.9 |
| Conjugated bilirubin umol/L | 5 | 12.8 | 23 | 4 | 32.6 |
| Alkaline phosphatase U/L | 100 | 62 | 87 | 131 | 233 |
| Alanine aminotransferase U/L | 28 | 21 | 43 | 35 | 68 |
| Asparagine aminotransferase UL | 17 | 30 | 118 | 23 | 22 |
| Blood urea mmol/L | 4.4 | 5.7 | 44.7 | 6 | 8.8 |
| Serum creatinine umol/L | - | 78 | 600 | 59 | 133 |
| Static binding assay details | |||||
| % Mature Troph/Schizonts before ex vivo culture | 25 | 40 | 17 | 10 | 10 |
| Hours ex-vivo culture | 10 | 14.5 | 10 | 10 | 12 |
| % Mature Troph/Schizonts at start of assay | 75 | 50 | 91 | 63 | 50 |