Table 1. Age and age-related phenotype EWAS DMR results.
| Phenotypea | Data (%) | Age Effectb | EWAS LMER-DMRsc | EWAS MZ-DMRse |
| Age | 100 | NA | 490 age DMRs | NA |
| Telomere length | 62.2 | −0.030±0.009 | - | NA |
| SBP | 100 | 0.663±0.146 | - | - |
| DBP | 100 | −0.019±0.098 | - | - |
| Lung function | 97.7 | −0.028±0.006 | cg16463460 (WT1) | - |
| Grip strength | 64.0 | −0.451±0.081 | - | NA |
| BMD | 86.7 | −0.005±0.001 | - | - |
| Serum DHEAS | 99.4 | −0.023±0.007 | - | - |
| Cholesterol | 97.1 | 0.052±0.012 | - | cg01136458 (CSMD1) |
| HDL | 97.1 | 0.016±0.012 | - | - |
| LDL | 94.8 | 0.018±0.011 | cg03001305 (STAT5A) d | cg01136458 (CSMD1) |
| Serum Albumin | 91.9 | −0.102±0.030 | - | - |
| Serum Creatinine | 86.0 | 0.120±0.102 | - | - |
| MLONG | 73.8 | 2.3×10−6±2.8×10−4 | cg09259772 (ARL4A)cg13870866 (TBX20) | NA |
| PLONG | 73.3 | 4.1×10−6±1.7×10−4 | - | NA |
| MREPROD | 80.8 | 6.3×10−6±5.3×10−4 | - | NA |
| PREPROD | 82.0 | 6.2×10−6±4.5×10−4 | - | NA |
Phenotypes are listed as follows: Telomere length, systolic blood pressure (SBP), diastolic blood pressure (DBP), Lung function (FVC), grip strength, bone mineral density (BMD), serum levels of DHEAS, serum total cholesterol, high density cholesterol (HDL), low density cholesterol (LDL), serum albumin, serum creatinine, maternal longevity (MLONG), paternal longevity (PLONG), and maternal age at reproduction (MREPROD), and paternal age at reproduction (PREPROD).
Regression coefficient estimate from the linear mixed effect regression model regressing raw phenotype on chronological age (age regression coefficient +/− se).
LMER-DMR results are shown at a permutation-based FDR threshold of 5%.
Results were significant when age was included as a fixed-effect covariate.
MZ-DMRs are shown at FDR 5% threshold, including age correction.