NRVMCs were transfected with a non-targeted control precursor miRNA (Con), a precursor miRNAs predicted to generate mature miR-455 (Pre-miR-455) (Panel A), or an anti-miR-455 mRNA (Anti-miR-455) (Panel C). After 48h, Calr levels were determined by immunoblotting. Shown are the mean Calr/GAPDH levels ± S.E. (n = 3 cultures per treatment) in cultures treated with pre-miR-455 (Panel B), or with anti-miR-455 (Panel D). *, p < 0.05 different from Con.