Table 1. ATF6-regulated Genes that are Putative Targets of ATF6-regulated miRNAs.
The ATF6-regulated mRNAs from a previous study [12] that are putative targets of the ATF6-regulated miRNAs from Figure 1A of this study were identified as described in the Methods, and are listed as genes 1-54 (Column 1), gene symbol (Column 2) and common name (Column 3). Also shown is the fold-change of each mRNA in response to ATF6 activation from the previous study (Column 4), as well as the name of the ATF6-regulated miRNA predicted to target the ATF6-regulated mRNA of interest (Column 5), and whether the miRNA was down-regulated (Column 6, red) or up-regulated (Column 6, green) by ATF6. ATF6-inducible mRNAs that are predicted targets of miR-455 are highlighted in yellow, and the names of known ER stress response genes are labeled in red in Column 2.
| 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|
| Number | ATF6-regulated mRNAs | ATF6-regulated mRNA Gene Names | mRNA Array Fold | ATF6- regulated miRNAs | miRNA Array Fold |
| 1 | SYCP2 | Synaptonemal complex protein 2 | 21.1 | miR-467f | 0.31 |
| SYCP2 | Synaptonemal complex protein 2 | 21.1 | miR-466f- 3p | 0.21 | |
| 2 | APPL1 | DCC-interacting protein 13-alpha | 9.3 | miR-467f | 0.31 |
| 3 | RTN4 | Reticulon-4 | 9.3 | miR-455 | 0.40 |
| 4 | MLLT3 | Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog | 8.7 | miR-466f-3p | 0.21 |
| 5 | THBS1 | Thrombospondin-1 Precursor | 7.2 | miR-202-3p | 0.48 |
| 6 | MXD1 | MAD protein (MAX dimerizer) | 6.5 | miR-202-3p | 0.48 |
| 7 | CHKA | Choline kinase alpha | 5.5 | miR-466f-3p | 0.21 |
| 8 | EDEM1 | ER degradation-enhancing alpha-mannosidase-like 1 | 5.4 | miR-466g | 0.38 |
| 9 | CALR | Calreticulin | 5.3 | miR-455 | 0.40 |
| 10 | MORF4L2 | Mortality factor 4-like protein 2 | 5.1 | miR-466g | 0.38 |
| 11 | XPO1 | Exportin-1 | 5.1 | miR-467f | 0.31 |
| 12 | UBFD1 | Ubiquitin domain-containing protein UBFD1 | 5.0 | miR-202-3p | 0.48 |
| UBFD1 | Ubiquitin domain-containing protein UBFD1 | 5.0 | miR-455 | 0.40 | |
| UBFD1 | Ubiquitin domain-containing protein UBFD1 | 5.0 | miR-299 | 0.39 | |
| 13 | RRAS2 | Ras-related protein R-Ras2 Precursor | 4.9 | miR-466f- 3p | 0.21 |
| RRAS2 | Ras-related protein R-Ras2 Precursor | 4.9 | miR-467f | 0.31 | |
| 14 | STRBP | Spermatid perinuclear RNA-binding protein | 4.9 | miR-202-3p | 0.48 |
| 15 | TMEM158 | Transmembrane protein 158 Precursor | 4.8 | miR-466f-3p | 0.21 |
| 16 | COL3A1 | Collagen alpha-1(III) chain Precursor | 4.6 | miR-202-3p | 0.48 |
| 17 | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 | 4.3 | miR-202-3p | 0.48 |
| 18 | SNAP23 | Synaptosomal-associated protein 23 | 4.2 | miR-202-3p | 0.48 |
| 19 | SENP2 | Sentrin-specific protease 2 | 4.2 | miR-202-3p | 0.48 |
| 20 | UGCGL1 | UDP-glucose:glycoprotein glucosyltransferase 1 Precursor | 3.7 | miR-202-3p | 0.48 |
| 21 | HN1 | Hematological and neurological expressed 1 protein | 3.5 | miR-455 | 0.40 |
| 22 | UCHL1 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 3.4 | miR-466g | 0.38 |
| 23 | WDR68 | WD repeat-containing protein 68 | 3.3 | miR-467f | 0.31 |
| 24 | EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 | 3.0 | miR-466g | 0.38 |
| 25 | EFNB2 | Ephrin-B2 Precursor | 3.0 | miR-467f | 0.31 |
| 26 | ENAH | Protein enabled homolog | 2.7 | miR-467e | 0.40 |
| 27 | JUNB | Transcription factor jun-B | 2.6 | miR-466f-3p | 0.21 |
| 28 | PJA2 | E3 ubiquitin-protein ligase Praja2 | 2.6 | miR-466f-3p | 0.21 |
| 29 | BMPR2 | Bone morphogenetic protein receptor type-2 Precursor | 2.6 | miR-467f | 0.31 |
| 30 | PJA2 | E3 ubiquitin-protein ligase Praja2 | 2.6 | miR-467f | 0.31 |
| 31 | SLC39A14 | Zinc transporter ZIP14 Precurso | 2.5 | miR-466g | 0.38 |
| 32 | INCENP | Inner centromere protein | 2.4 | miR-466g | 0.38 |
| 33 | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1 | 2.4 | miR-466f-3p | 0.21 |
| SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1 | 2.4 | miR-467f | 0.31 | |
| 34 | KLHL2 | Kelch-like protein 2 | 2.4 | miR-466f-3p | 0.21 |
| KLHL2 | Kelch-like protein 2 | 2.4 | miR-467f | 0.31 | |
| 35 | ING1 | Inhibitor of growth protein 1 | 2.4 | miR-467f | 0.31 |
| 36 | ARL4C | ADP-ribosylation factor-like protein 4C | 2.3 | miR-466g | 0.38 |
| 37 | LRRC59 | Leucine-rich repeat-containing protein 59 | 2.2 | miR-202-3p | 0.48 |
| 38 | SLC6A6 | Sodium- and chloride-dependent taurine and beta-alanine transporter | 2.2 | miR-466f-3p | 0.21 |
| 39 | CUGBP2 | CUG-BP- and ETR-3-like factor 2 | 2.2 | miR-466g | 0.38 |
| 39 | CUGBP2 | CUG-BP- and ETR-3-like factor 2 | 2.2 | miR-467f | 0.31 |
| 40 | CALM1 | Calmodulin | 2.2 | miR-202-3p | 0.48 |
| 41 | CDS2 | Phosphatidate cytidylyltransferase 2 | 2.1 | miR-466f-3p | 0.21 |
| 42 | PPAP2A | Lipid phosphate phosphohydrolase 1 | 2.1 | miR-202-3p | 0.48 |
| 43 | FSTL1 | Follistatin-related protein 1 Precursor | 2.1 | miR-363 | 0.43 |
| FSTL1 | Follistatin-related protein 1 Precursor | 2.1 | miR-466g | 0.38 | |
| 44 | WDR1 | WD repeat-containing protein 1 | 2.0 | miR-467e | 0.40 |
| 45 | SMAD2 | Mothers against decapentaplegic homolog 2 | 2.0 | miR-455 | 0.40 |
| 46 | A2BP1 | Ataxin 2 binding protein 1 | 0.3 | miR-17 | 2.00 |
| 47 | SLC40A1 | Solute carrier family 40 (iron-regulated transporter), member 1 | 0.4 | miR-17 | 2.00 |
| 48 | HLF | Hepatic leukemia factor | 0.4 | miR-17 | 2.00 |
| 49 | CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.5 | miR-17 | 2.00 |
| 50 | HLF | Hepatic leukemia factor | 0.4 | miR-721 | 2.50 |
| HLF | Hepatic leukemia factor | 0.4 | miR-130b | 2.17 | |
| 51 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | 0.4 | miR-721 | 2.50 |
| ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | 0.4 | miR-130b | 2.17 | |
| 52 | UCP3 | Mitochondrial uncoupling protein 3 | 0.3 | miR-721 | 2.50 |
| UCP3 | Mitochondrial uncoupling protein 3 | 0.3 | miR-130b | 2.17 | |
| 53 | TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 | 0.2 | miR-721 | 2.50 |
| TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 | 0.2 | miR-130b | 2.17 | |
| 54 | FNDC5 | Fibronectin type III domain-containing protein 5 Precursor | 0.2 | miR-671-5 | 2.35 |