Table 2.
Outcome scores at three study points by intervention group
| Measure | Mean (SD) SPARX* group | Mean (SD) treatment as usual group | |||||
|---|---|---|---|---|---|---|---|
| Baseline | Post-intervention | 3 month follow-up | Baseline | Post-intervention | 3 month follow-up | ||
| Primary outcome | |||||||
| CDRS-R: | |||||||
| PP n=143 | 44.28 (11.13) | 34.14 (11.93) | 29.47 (9.70) | 43.78 (9.67) | 36.71 (11.05) | 30.75 (8.73) | |
| ITT n=187 | 43.02 (11.12) | 33.92 (11.19) | 28.96 (9.11) | 42.09 (10.38) | 35.07 (9.71) | 29.37 (9.87) | |
| Secondary outcomes | |||||||
| RADS-2: | |||||||
| PP n=143 | 76.16 (13.35) | 65.44 (14.89) | 60.87 (15.01) | 77.99 (13.46) | 70.21 (13.43) | 62.73 (14.84) | |
| ITT n=187 | 74.83 (13.35) | 65.19 (14.52) | 60.68 (12.51) | 75.52 (14.42) | 68.24 (12.31) | 61.45 (14.68) | |
| MFQ: | |||||||
| PP n=143 | 28.73 (11.68) | 19.02 (12.56) | 15.97 (10.84) | 32.25 (11.48) | 24.74 (11.89) | 19.27 (11.46) | |
| ITT n=187 | 27.59 (12.15) | 19.10 (12.29) | 15.77 (10.02) | 29.41 (12.99) | 22.96 (11.87) | 17.92 (11.88) | |
| PQ-LES-Q: | |||||||
| PP n=143 | 27.78 (9.40) | 33.17 (10.39) | 34.99 (10.04) | 26.39 (8.49) | 29.93 (9.23) | 33.79 (8.75) | |
| ITT n=187 | 28.35 (9.24) | 33.29 (8.92) | 35.14 (8.32) | 28.13 (9.85) | 31.26 (7.89) | 34.87 (8.93) | |
| Kazdin HPLS: | |||||||
| PP n=143 | 6.41 (4.15) | 4.09 (3.78) | 3.43 (3.30) | 6.61 (4.29) | 5.40 (4.32) | 3.74 (3.56) | |
| ITT n=187 | 6.17 (3.98) | 4.31 (4.00) | 3.61 (2.75) | 6.15 (4.32) | 4.99 (3.93) | 3.54 (3.52) | |
| SCAS (total) | |||||||
| PP n=143 | 39.19 (16.03) | 29.91 (15.24) | 25.96 (15.28) | 38.53 (15.69) | 32.55 (14.99) | 27.98 (15.25) | |
| ITT n=187 | 37.74 (16.44) | 28.86 (12.23) | 25.60 (10.32) | 35.36 (16.30) | 29.97 (12.23) | 26.25 (11.28) | |
| Separation anxiety: | |||||||
| PP n=143 | 4.07 (2.55) | 3.07 (2.46) | 2.31 (2.17) | 4.54 (3.37) | 3.90 (3.34) | 3.18 (2.80) | |
| ITT n=187 | 3.79 (2.56) | 2.91 (2.15) | 2.25 (2.24) | 4.15 (3.17) | 3.66 (2.95) | 3.00 (2.37) | |
| Social phobia: | |||||||
| PP n=143 | 9.16 (3.66) | 7.56 (3.58) | 6.96 (3.66) | 8.67 (3.37) | 7.40 (3.51) | 7.01 (3.57) | |
| ITT n=187 | 8.63 (3.88) | 7.27 (3.64) | 6.72 (2.71) | 8.03 (3.55) | 6.67 (3.03) | 6.57 (2.83) | |
| Obsessive-compulsive disorder: | |||||||
| PP n=143 | 6.32 (3.63) | 4.56 (3.42) | 3.39 (3.21) | 6.53 (4.01) | 5.55 (3.82) | 4.09 (3.86) | |
| ITT n=187 | 6.46 (3.71) | 4.61 (3.24) | 3.66 (2.63) | 5.92 (4.17) | 5.17 (3.21) | 3.77 (2.71) | |
| Panic/agoraphobia: | |||||||
| PP n=143 | 6.77 (5.15) | 4.58 (4.65) | 3.86 (4.04) | 6.07 (4.62) | 4.63 (3.80) | 4.00 (3.87) | |
| ITT n=187 | 6.45 (5.09) | 4.40 (3.65) | 3.82 (2.93) | 5.44 (4.55) | 4.08 (3.69) | 3.52 (3.27) | |
| Physical injury fears: | |||||||
| PP n=143 | 4.61 (2.93) | 3.98 (2.89) | 3.85 (2.85) | 4.32 (3.27) | 3.82 (3.04) | 3.78 (2.69) | |
| ITT n=187 | 4.43 (3.11) | 3.73 (1.94) | 3.76 (1.79) | 4.10 (3.27) | 3.61 (1.90) | 3.62 (1.97) | |
| Generalised anxiety: | |||||||
| PP n=143 | 8.18 (3.39) | 6.12 (3.39) | 5.51 (3.52) | 8.39 (3.25) | 7.41 (2.94) | 5.89 (2.94) | |
| ITT n=187 | 7.92 (3.57) | 6.01 (2.96) | 5.47 (2.89) | 7.69 (3.43) | 6.61 (3.04) | 5.51 (2.81) | |
CDRS-R=children’s depression rating scale-revised; PP=per protocol population; ITT=intention to treat population; RADS-2=Reynolds adolescent depression scale—second edition; MFQ=mood and feelings questionnaire; PQ-LES-Q=pediatric quality of life enjoyment and satisfaction questionnaire; Kazdin HPLS=Kazdin hopelessness scale for children; SCAS=Spence children’s anxiety scale.
For intention to treat population the means and standard deviations at post-intervention and at three month follow-up include individual imputed estimates.
*Computerised cognitive behavioural therapy intervention.