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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Nat Immunol. 2012 Mar 25;13(5):465–473. doi: 10.1038/ni.2260

Figure 4. Del-1 deficiency-associated inflammatory bone loss is prevented in mice with dual Del-1–IL-17R deficiency.

Figure 4

(a) Twenty-week-old C57BL/6 wild-type (WT) mice or mice with the indicated genetic deficiencies were assessed for periodontal bone heights (for details see fig. 3a legend). (b) Five-week-old WT mice or mice with the indicated deficiencies were assessed for periodontal bone heights. (c) The mice in a were assessed for numbers of oral anaerobic bacteria. (e) Changes to the composition of the oral microbiota detected by aerobic (left) or anaerobic (right) culture in mice with single or combined Del-1 deficiencies and their wild-type littermate controls. CFU for each organism are shown as a proportion of the total cultured organisms. Data are means ± SD (n ≥ 6 mice per group) from one of two independent sets experiments that yielded similar results. *P <0.01 compared to WT control.