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. Author manuscript; available in PMC: 2013 Dec 5.
Published in final edited form as: Physiol Behav. 2012 Jan 8;107(5):649–662. doi: 10.1016/j.physbeh.2011.12.025

Figure 8. Morris water maze learning and reversal in B6 and BTBR.

Figure 8

(A) Both B6 and BTBR acquired the initial hidden platform location over 7 training days. During the reversal learning phase, B6 showed decreased latency to reach the new hidden platform location over 4 days. In contrast, BTBR did not show significant improvement over 4 days. The two strains did not differ on latency to reach the platform. (B) During the initial acquisition phase, BTBR swam significantly faster than B6. During the reversal learning phase, the two strains did not differ significantly on swim speed (C) During the initial acquisition phase, both strains showed decreased distance traveled over 7 days. Distance to reach the platform was longer in BTBR than in B6. During the reversal learning phase, B6 showed decreased distance traveled over 4 days. BTBR did not show significant improvement over 4 days. (D) In the probe trial after the initial acquisition, both strains spent significantly more time in the training quadrant than in the other three quadrants. In the probe trial after reversal learning, B6 spent more time in the trained quadrant than two other quadrants (p<.05) and made more crossings over the trained quadrant location. BTBR spent significantly more time in the trained platform location than two other equivalent locations. (In the probe trial after acquisition training, both strains made more crossings over the initial trained platform location than over equivalent locations in 2 or more quadrants. In the probe trial after the reversal training, B6 made more crossings over the new trained quadrant location, whereas BTBR did not show selective quadrant search. * p<.05 between strains; (D, E): *p<.05 vs. other quadrants. Acquisition: B6, N=16; BTBR, N=18. Reversal: B6, N=11; BTBR, N=14.