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. 2012 Apr 20;5:51. doi: 10.3389/fnmol.2012.00051

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Copyright © 2012 Cole, Kean, Pollard, Verma and Watson.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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Glucose-6-phosphate reduces microsomal SERCA hydrolytic activity, as quantified by decreased release of inorganic phosphate in comparison to other hexose phosphates tested. Glucose-6-phosphate (10 mM) significantly reduced (p < 0.05) the release of inorganic phosphate from brain ER microsomes after 6 min incubation. Neither glucose-1-phosphate (10 mM) nor fructose-6-phosphate (10 mM) altered phosphate release (p > 0.05) in comparison to control. Data are means ± SEM for n = 7. ^abMeans with differing superscripts are significantly different, p < 0.05, while means that share superscripts are not significantly different.