Figure 6.

After 6 min of incubation, glucose-6-phosphate demonstrated a trend toward reduced accumulation of ⁴⁵Ca²⁺ in brain ER microsomes. Addition of glucose-6-phosphate (10 mM) demonstrated a trend toward reduced accumulation of calcium (p < 0.10), while thapsigargin (1 μM) reduced ER Ca²⁺ accumulation (p < 0.05). When combined, the treatments additively reduced ER Ca²⁺ accumulation (p < 0.05) in comparison to control. Data are means ± SEM for n = 5. Each microsomal preparation contained a minimum of eight whole brains pooled together. ^abcMeans with differing superscripts are significantly different, p < 0.05, while means that share superscripts are not significantly different.