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. Author manuscript; available in PMC: 2013 Apr 12.
Published in final edited form as: J Med Chem. 2012 Mar 20;55(7):3088–3100. doi: 10.1021/jm2015183

Scheme 2.

Scheme 2

Elaboration of Selected N-Benzoyl-2-hydroxybenzamides

Reagents and conditions: (a) Pd/C, H2, MeOH, room temp, 18 h; (b) methyl 3-(chlorocarbonyl)propanoate, pyridine, CH2Cl2, room temp, 1 h; (c) TIPSCl, Et3N, DMAP, DMF, room temp, 3.5 h, (d) 8-[(benzyloxy)amino]-8-oxooctanoyl chloride, pyridine, CH2Cl2, room temp, 2 h.