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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Nature. 2011 Oct 30;480(7375):123–127. doi: 10.1038/nature10579

Figure 1. Wildtype salivary gland endocycles.

Figure 1

a-c) In situ hybridization of WT 72h AED glands to the indicated mRNAs. d-f) WT salivary glands at 72h AED double-labeled for: d) E2F1 (green) and BrdU (red); e) CycE (red) and BrdU (green); f) CycE (red) and E2F1 (green). Graphs show nuclear concentrations measured from micrographs of 2–3 glands, in which each dot represents one nucleus. Shaded region (blue) shows trajectory of E2F1/CycE oscillations with an arrow indicating the expected temporal progression. g) Simplified schematic of the computational model. See Fig S4. h) Time plot for WT predicted by the model. i) Nuclear concentrations predicted by the model; arrow represents temporal progression.