Figure 2.
Quantification of BrdUrd-positive cells in dentate gyrus after kainic acid injection (A) or MCAO (B) in FGF-2+/+ (empty bars) and FGF-2−/− mice (filled bars). The number of BrdUrd-labeled cells was counted on days 9 or 16 after injury (see Materials and Methods). Note the large early increase in labeled cells after kainic acid and MCAO, which was attenuated at both time points in the FGF-2−/− mice. The ordinate scale reflects the counts in the total dentate gyrus (means + SD, n = 6 per group). +, P < 0.05 compared with sham control. *, P < 0.01 compared with FGF-2+/+ littermates on the same day of death.