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. 2011 Nov 30;108(5):515–520. doi: 10.1038/hdy.2011.115

Table 1. Interaction of QTL with LSB and LSW.

QTL Location
 Confidence interval Trait Full LPR Interaction effect (estimate) Test
  cM Mb          
LSB1.1 42.66 93.21 87.02–99.36 Week 1 4.18 a (0.036) 1.58
      87.02–99.36 Week 2 6.85 a (0.063) 2.98
      87.02–99.36 Week 3 3.30 a (0.078) 1.98
LSB4.1 37.28 84.31 78.87–87.93 Week 4 5.11 −a (−0.161) 2.43
        Week 5 5.02 −a (−0.172) 1.85
        Week 6 6.06 −a (−0.195) 1.72
LSB6.1 29.25 65.37 105.62–117.19 Week 4 7.79 −i (−0.131) 1.69
      94.76–134.72 Week 5 7.44 −i (−0.181) 1.99
      94.76–134.72 Week 6 7.21 −i (−0.242) 2.43
      94.76–134.72 Week 7 6.76 −i (−0.302) 2.82
      94.76–134.72 Week 8 6.50 −i (−0.320) 2.64
      94.76–134.72 Week 9 6.97 −i (−0.406) 3.50
      94.76–134.72 Week 10 5.68 −i (−0.384) 2.86
      94.76–134.72 Growth 3–10 4.99 −i (−0.003.) 2.44
LSW10.1 49.16 111.3 99.22–117.08 Week 4 2.66 −d (−0.223) 2.62
      99.22–128.85 Week 5 4.59 −d (−0.265) 2.41
      99.22–117.08 Week 6 3.86 −d (−0.263) 1.79
      99.22–128.85 Week 7 3.97 −d (−0.295) 1.73
      99.22–117.08 Week 8 4.88 −d (−0.370) 2.12
      99.22–117.08 Week 9 4.68 −d (−0.383) 1.99
      99.22–117.08 Week 10 4.72 −d (−0.443) 2.30
LSB11.1 11.90 24.47 60.48–72.28 Week 4 2.37 d (0.243) 3.14
LSW15.1 30.19 69.47 62.91–76.75 Week 2 3.49 d (0.074) 2.71
      56.81–83.18 Week 3 4.63 d (0.127) 3.15
      62.91–76.75 Week 4 2.16 d (0.162) 1.66
LSB16.1 44.61 46.92 36.99–50.54 Week 5 2.16 d (−0.336) 3.73
      36.99–50.54 Week 6 2.84 d (−0.454) 4.64
      36.99–50.54 Week 7 3.32 d (−0.559) 5.27
      36.99–50.54 Week 8 2.90 d (−0.613) 5.14
      36.99–50.54 Week 9 2.72 d (−0.624) 4.70
      36.99–50.54 Week 10 2.95 d (−0.713) 5.36
      36.99–50.54 Growth 310 3.81 d (−0.714) 6.10

Abbreviations: cM, centiMorgans; LPR, log probability ratio; LSB, litter size at birth; LSW, litter size at weaning; Mb, megabases; QTL, quantitative trait locus. [2]The first column identifies the QTL followed by the genomic location in F2 equivalent cM and the coordinates in Mb based on mouse genome build 36. This is followed by the traits affected. The column ‘Full LPR' lists the overall model LPR for the test of main effects and interaction effects. Under ‘Interaction effect' we specify which of the three effects showed an interaction with the sign of effect, where ‘a' refers to additive, ‘d' to dominance and ‘i' to imprinting effects. In parentheses we give the interaction estimates. The column headed ‘Test' gives the LPR for the interaction effect. ‘Growth 13' and ‘Growth 310' refer to preweaning and postweaning growth, respectively. Confidence intervals (Mb) for the interaction QTL positions were determined using a one LOD drop (using LPR values) following Lander & Botstein (1989). As a locus may affect several traits, the LPR for the interaction effects may be different and hence the confidence intervals.