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. 2001 Apr 24;98(10):5880–5885. doi: 10.1073/pnas.101524998

Figure 2.

Figure 2

Effects of PTK and PTP inhibitors on modulation of rod CNG channels by IGF-I. (A) IGF-I (1 μM) was either included in the patch pipette to selectively activate IGF-I receptors near the channels (n = 5) or was applied outside the pipette after seal formation to exclude activation of receptors near the channels (n = 7). (B) The effect of IGF-I is blocked by PTK inhibitors (10 μM Lav A; n = 7) and PTP (100 μM pervanadate; n = 7), but not by serine/threonine phosphatase inhibitors (okadaic acid and calyculin A; n = 7–11).