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. Author manuscript; available in PMC: 2012 Apr 20.
Published in final edited form as: Curr Pharm Des. 2011 Dec;17(38):4294–4307. doi: 10.2174/138161211798999438

Figure 2.

Figure 2

General features of the cyclic cystine knot (CCK) topology found in cyclotides. A. Detailed structure the cystine knot core and the connecting loops. The six Cys residues are labeled I through VI whereas loops connecting the different Cys residues are designated as loop 1 through 6, in numerical order from the N- to the C-terminus. B. Möbius (right) and bracelet (left) cyclotides are defined by the presence (Möbius) or absence (bracelet) of a Pro residue in loop 5 that introduces a twist in the circular backbone topology.