Skip to main content
. Author manuscript; available in PMC: 2012 Apr 20.
Published in final edited form as: Curr Pharm Des. 2011 Dec;17(38):4294–4307. doi: 10.2174/138161211798999438

Figure 6.

Figure 6

Summary of some of the modifications made to kalata B1 and MCoTI-II to elicit novel biological activities. Modifications include the grafting of peptides onto various loops of kalata B1 [75] and MCoTI-II [17, 134, 135]. Cyclotide based libraries have been also generated using loops 1, 2, 3, 4 and 5 of MCoTI-I to study the effect of individual mutations on the biological activity and folding ability of MCoTI-I mutants [20]. The locations of the changes introduced into the cyclotide framework are illustrated using the MCoTI-II structure (pdb ID: 1IB9).