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. 2012 Jan 24;302(7):E841–E851. doi: 10.1152/ajpendo.00599.2011

Fig. 5.

Fig. 5.

Analysis by microcomputed tomography (μCT) of effects of continuous PTH infusion on cortical bone parameters. A: representative μCT reconstructed cross-sections of femurs from 12-wk-old WT, Pth−/−, and Pth−/−-Casr−/− mice infused with 60 μg·kg−1·day−1 hPTH(1–34) or vehicle for 2 wk. Analysis by μCT of femur cortical bone showing bone volume/cortical volume (BV/CtV; B), cortical volume (C), closed porosity [Po(cl); D], and open porosity [Po(op); E]. Each value is the mean ± SE (n = 8/genotype). Symbols indicate significant changes using 1-way ANOVA, as described in Statistical analysis. *P < 0.05 and **P < 0.01 compared with vehicle-infused mice of the corresponding genotype. #P < 0.05 and ##P < 0.01 compared with PTH-infused Pth−/− mice. Results of 2-way ANOVA using genotype (Pth−/− and Pth−/−-Casr−/−) and PTH infusion treatment (vehicle and PTH infusion) as main effects: BV/CtV: genotype, P = 0.001; PTH, P < 0.001; genotype × PTH, P = 0.016. Cortical volume: genotype, P = 0.029; PTH, P < 0.001; genotype × PTH, P = 0.049. Po(cl): genotype, P = 0.003; PTH, P < 0.001; genotype × PTH, P = 0.003. Po(op): genotype P = 0.002; PTH, P < 0.001; genotype × PTH, P = 0.021.