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. 2012 Jan 12;302(7):G664–G675. doi: 10.1152/ajpgi.00430.2011

Fig. 8.

Fig. 8.

A: predominant role of RhoA/ROCK pathway in the intact human IAS was confirmed by a significant correlation (*P < 0.05; n = 4 to 5) between the decreases in the IAS tone and ROCK activity vs. PKC activity (P > 0.05). In these experiments, Y 27632 and Gö 6850 cause a significant and concentration-dependent decrease in the IAS tone and in the ROCK activity (*P < 005). However, the decreases in the IAS tone and ROCK activity are significantly higher that correlate significantly only in the case of Y 27632 (*P < 0.05). Gö 6850 and calphostin C cause a significant decrease in the PKC activity (*P < 0.05), whereas Y 27632 has no significant effect (P > 0.05). These correlations are further evident in the decreases in the IAS tone and p-MYPT1 (B).