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Effects of varying persistent late Na+ current (INa,L) on SAN activity. i and ii: results of simulations from central (i) and peripheral (ii) SAN cells. A–F: corresponding effects on action potentials (APs; A), cycle lengths (CLs; B), AP durations (APD; C), peak amplitudes (D), maximum change in voltage over time [(dV/dt)max] values (E), and maximal diastolic potential (MDP; F).
