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Effects of a contribution from INa,L of magnitude 6% of the control INaT in combination with varying INa,T of 100% (A), 80% (B), 70% (C), and 35% (D) of the control INa,T on AP conduction in a 2-D tissue model of the SAN coupled to the atrial septum (upward direction) and atrial muscle (downward direction). E and F: calculated conduction times (E) from the SAN center to the atrial septum or atrial muscle and the CLs (F) with the corresponding INa,L values.
