Table 6.

Systolic and diastolic indexes in HCR-M, LCR-M, HCR-F, and LCR-F rats obtained by in vivo cine MRI

Main Effect	P Value	HCR-M	LCR-M	HCR-F	LCR-F
Number of rats/group		10	9	9	10
Age at MRI, wk
Strain	0.81	23.6 ± 0.04c	23.7 ± 0.04	23.8 ± 0.03	23.7 ± 0.06
Sex	0.145
Interaction	0.022
Septum thickness, mm
Strain	0.008	1.74 ± 0.004c	1.88 ± 0.007d	1.44 ± 0.005	1.62 ± 0.006b
Sex	<0.001
Interaction	0.751
Septal wall thickness/TL, mm
Strain	0.055	4.25 ± 0.10	4.48 ± 0.18	3.99 ± 0.14	4.35 ± 0.156
Sex	0.217
Interaction	0.654
Heart rate, beats/min
Strain	0.991	345 ± 12.9	342 ± 11.5	346 ± 12.9	349 ± 11.9
Sex	0.731
Interaction	0.824
EDV, μl
Strain	0.434	562 ± 25.7c	532 ± 21.2d	377 ± 26.2	369 ± 19.7
Sex	<0.001
Interaction	0.645
End-systolic volume, μl
Strain	0.355	99 ± 10.1c	83 ± 11.8d	53 ± 5.6	53 ± 6.7
Sex	<0.001
Interaction	0.390
Stroke volume, μl
Strain	0.630	462 ± 24.4c	449 ± 17.7d	323 ± 24.3	316 ± 15.7
Sex	<0.001
Interaction	0.882
Systolic indexes
Cardiac output, ml/min
Strain	0.634	161 ± 12.8c	153 ± 7.3d	112 ± 9.6	110 ± 6.5
Sex	<0.001
Interaction	0.754
Cardiac index, ml·min−1·g−1
Strain	0.002	0.43 ± 0.030c	0.33 ± 0.018a,d	0.52 ± 0.032	0.43 ± 0.028b
Sex	0.002
Interaction	0.699
Ejection fraction, %
Strain	0.427	82.2 ± 1.67	84.5 ± 1.89	85.7 ± 1.28	86.0 ± 1.41
Sex	0.128
Interaction	0.539
Diastolic indexes
Diastolic relaxation time, ms
Strain	0.038	38.9 ± 3.05c	39.6 ± 3.96	27.6 ± 3.06	42.1 ± 3.79b
Sex	0.220
Interaction	0.056
Peak filling rate, μl/ms
Strain	0.598	12.2 ± 1.05c	11.8 ± 0.74d	8.5 ± 0.84	8.1 ± 0.46
Sex	<0.001
Interaction	0.981
Initial filling rate, μl/ms
Strain	0.246	4.2 ± 0.85	5.1 ± 1.07d	4.9 ± 0.50	2.1 ± 0.56b
Sex	0.147
Interaction	0.023

Values are means ± SE.

^aP < 0.05, HCR-M vs. LCR-M;

^bP < 0.05, HCR-F vs. LCR-F;

^cP < 0.05, HCR-M vs. HCR-F;

^dP < 0.05, LCR-M vs. LCR-F.