Figure 5.

Treatment of gentamicin-damaged vestibules with GF II resulted in the return of type 1 hair cells. (A–C) Transmission electron micrographs presenting regions of HC renewal from the horizontal cristae of control (A), gentamicin-exposed, untreated (B), and gentamicin-exposed, GF II-treated (C) guinea pigs. Type 1 HCs (1) and their calyx type nerve and endings (asterisks) are evident in both control (A) and GF II-treated (C) cristae, but not in the gentamicin-exposed, untreated (B) crista where only two type 2 HCs with button-type nerve endings (arrowhead) were identifiable. (Scale bars = 5 μm.)