Table 2.
Hemodynamics of conscious and anesthetized TG rats and NTLs
| Parameter | n | Conscious | n | Anesthetized |
|---|---|---|---|---|
| Heart rate, beats/min | ||||
| NTL | 8 | 354 ± 8.3 | 5 | 409 ± 21† |
| TG | 8 | 284 ± 8.6** | 5 | 347 ± 15*†† |
| LV systolic pressure, mmHg | ||||
| NTL | 8 | 142 ± 7.3 | 5 | 111 ± 5.5† |
| TG | 8 | 141 ± 6.4 | 5 | 113 ± 6.8† |
| End-diastolic pressure, mmHg | ||||
| NTL | 8 | 6.0 ± 1.2 | 5 | 8.3 ± 1.3 |
| TG | 8 | 6.3 ± 0.6 | 5 | 7.5 ± 1.4 |
| Systolic arterial pressure, mmHg | ||||
| NTL | 8 | 139 ± 4.9 | 5 | 117 ± 7.3† |
| TG | 8 | 139 ± 7.4 | 5 | 113 ± 4.1† |
| Diastolic arterial pressure, mmHg | ||||
| NTL | 8 | 91 ± 4.4 | 5 | 83 ± 7.5 |
| TG | 8 | 91 ± 6.9 | 5 | 80 ± 4.4 |
| Mean arterial pressure, mmHg/s | ||||
| NTL | 8 | 110 ± 4.6 | 5 | 96 ± 7.6 |
| TG | 8 | 111 ± 7.6 | 5 | 92 ± 4.4 |
| LV +dP/dt, mmHg/s | ||||
| NTL | 8 | 6,692 ± 377 | 5 | 6,087 ± 493 |
| TG | 8 | 12,301 ± 746** | 5 | 7,954 ± 526*†† |
| LV −dP/dt, mmHg/s | ||||
| NTL | 8 | −5,212 ± 299 | 5 | −4,718 ± 877 |
| TG | 8 | −6,722 ± 518* | 5 | −4,783 ± 712† |
| Tau, ms | ||||
| NTL | 8 | 21 ± 2.5 | 5 | 22 ± 3.5 |
| TG | 8 | 13 ± 1.2* | 5 | 15 ± 1.9 |
Values are means ± SE; n, no. of rats. Hemodynamics recorded by fluid catheter were compared between conscious and anesthetized NTLs and TG rats. TG vs. NTL:
*
P < 0.05 and
**
P < 0.01. Anesthetized vs. conscious:
†
P < 0.05 and
††
P < 0.01.