Fig. 2.

Formation process of EADs in different models. A: simultaneous recordings of whole cell (global) Ca²⁺ transients (CaTs) and APs at 5 min after treatment with 200 μM H₂O₂. Note the increase of CaT amplitude (F/F₀) following the emergence of EADs. B: same as A, except that the myocyte was treated with Iso + BayK (10 s after treatment). Note the Ca²⁺ accumulation before the emergence of EADs. Spontaneous Ca²⁺ transients or Ca²⁺ waves (SCaTs/CaWs) are indicated by ○ and *, which correspond to APD prolongation and EADs (arrows), respectively. Spontaneous CaT (S) and triggered APs (T) are also shown.