Table 1.
Comparison of Ca2+ handling properties in the two EAD models
| Model | CaT at Control | CaT After Treatment | Spontaneous CaT/CaW | SR Content at Control | SR Content After Treatment |
|---|---|---|---|---|---|
| H2O2 | 1.56 ± 0.27 (48) | 1.54 ± 0.32 (42) | 1.26 ± 0.09† (27) | 1.67 ± 0.57 (19) | 1.52 ± 0.35 (19) |
| Iso + BayK | 1.44 ± 0.20 (44) | 1.75 ± 0.37* (49) | 1.65 ± 0.24 (32) | 1.62 ± 0.35 (26) | 1.99 ± 0.54‡ (24) |
Values are means ± SD; numbers of calcium transients (CaTs) measured from multiple cells are indicated in the parenthesis. Amplitude (F/F0) of CaT, spontaneous CaT/calcium wave (CaW), and 10-mM caffeine-induced calcium release [sarcoplasmic reticulum (SR) content] are listed.
EAD, early afterdepolarization; Iso, isoproterenol; BayK, BayK 8644.
*
P < 0.01, compared with CaT at control;
†
P < 0.01, compared with CaT after treatment;
‡
P < 0.01, compared with SR content at control.