Table 2. Inhibition of LysRS/CA, LysRS/WM CA-CTD, and LysRS/GagΔp6 Interaction by CP1-CP6.
| IC50 (μM)a |
|||
|---|---|---|---|
| peptide | LysRS/CA | LysRS/WM CA-CTD | LysRS/GagΔp6 |
| CP1 | 5.3 ± 0.8 | NI | NI |
| CP2 | 0.61 ± 0.04 | 0.97 ± 0.1 | 1.5 ± 0.5 |
| CP3 | 23 ± 3 | 16 ± 3 | |
| CP4 | 0.91 ± 0.1 | 0.53 ± 0.1 | 1.1 ± 0.3 |
| CP5 | NI | 63 ± 40 | |
| CP6 | NI | 15 ± 3 | |
a
IC50 values were determined from FA inhibition measurements as described in Methods. Reported values are averages of three trials with the standard deviation indicated. A dash indicates the experiment was not performed. NI, no significant inhibition observed.