RPA of FGF-3 (A) and cyclin mRNAs (B) in
the lungs of 1138H bitransgenic mouse lungs after the administration
and withdrawal of 500 μg/kg RU486. −, RNA from mice treated with
placebo; On 1 wk, mice treated with RU486 for 1 week; On 2 wks, mice
treated with RU486 for 2 weeks; Off 1 wk, mice after withdrawal of
RU486 for 1 week; Off 2 wks, mice after the withdrawal of RU486 for 2
weeks after treatment with RU486; Re-on 2 wks, mice treated with RU486
after withdrawal of RU486 for 2 weeks. Expression of cyclophillin (cph)
served as a control for RNA-loading analysis of FGF-3 expression.
Expression of L32 served as a control for RNA loading for cyclin gene
expression (data not shown). Each lane represents an independent mRNA
from an individual mouse.