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. 2012 Jan 4;107(7):1881–1889. doi: 10.1152/jn.00715.2011

Fig. 3.

Fig. 3.

DCS has similar effects on evoked fEPSPs in both basal and apical dendrites of CA1 neurons. A and C: positions of the DCS electrodes. Stimulating platinum-iridium (Pt-Ir) electrode is positioned at association fibers in stratum oriens in A and at Schaffer collaterals in C. The recording glass electrodes are positioned at basal or apical CA1 dendrites, respectively. B: the cumulative data based on the results shown in Fig. 2 reveal significant inhibition of fEPSPs in basal CA1 dendrites in all studied amplitudes of cathodal DCS. Values of fEPSP slope are 0, 33 ± 12, 75 ± 10, 110 ± 8, and 97 ± 5% for DCS of −400, −200, −100, +100, and +200 μA DCS, respectively. One-way ANOVA demonstrate significant dependence of average fEPSP slope on the DCS condition F(4,26) = 25.6; P = 0.0001. D: cathodal DCS also inhibits fEPSPs at apical dendrites of CA1 neurons. However, anodal DCS facilitates apical fEPSPs at 100 μA, but further increase in anodal DCS leads to inhibition of the fEPSPs. Values of fEPSP slope are 72 ± 1, 84 ± 6, 91 ± 4, 109 ± 2, and 91 ± 2% for DCS of −400, −200, −100, +100, and +200 μA, respectively. One-way ANOVA demonstrate significant dependence of average fEPSP slope on the DCS condition F(4,22) = 7.77; P = 0.0005. Numbers of slices are 3, 5, 10, 5, and 4 for −400, −200, −100, +100, and +200 μA of DCS, respectively. *P < 0.05, **P < 0.01, and ***P < 0.001.