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Polarized sorting of APP in MDCK cells. (A) Two independent basolateral sorting pathways for αAPPs via a NH4Cl-sensitive compartment (blue) and full-length APP (red). (B) Inhibition of vesicular acidification by NH4Cl leads to random secretion of αAPPs whereas full-length APP is still sorted to the basolateral membrane. (C) APP lacking a cytoplasmic signal for basolateral sorting (ΔC APP) undergoes random surface transport.
