Table 1.

Models of human immune systems in immunodeficient mice

Model	Characteristics	Uses
Hu-PBL-SCID	Immunodeficient mice engrafted with human PBMCs	Study of human-specific infectious agents, alloimmunity and autoimmunity in vivo
Hu-SRC-SCID	Immunodeficient mice engrafted with human HSCs	Study of human HSC and development of a functional human immune system
SCID-hu (BLT)	Immunodeficient mice engrafted under the renal capsule with human fetal liver/thymus and injected IV with fetal liver HSC	Study of human HSC, T-cell development and intrathymic selection and development of a functional human immune system

Abbreviations: PBL, peripheral blood leukocytes; PBMCs, peripheral blood mononuclear cell cultures; SRC, scid-repopulating cell; BLT, bone marrow/liver/thymus; HSCs, hematopoietic stem cells.