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. 2012 Apr 13;61(5):1250–1262. doi: 10.2337/db11-1109

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© 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 2. — PDG cell replication is increased by exendin-4 treatment in rats. The frequency of replication ascertained by Ki-67 immunostaining (red; colabeled with cytokeratin [CK] in green) was increased in PDGs compared with adjacent duct cells (*lumen of the large duct) in both control (A) and exendin-4–treated (B) rats. Replication frequency showed variation within the PDGs in control (C) as well as exendin-4–treated (D) animals. E: However, both the abundance of PDGs and the frequency of replication were increased by exendin-4 treatment. Exendin-4 also increased replication in main duct cells but not in the duct cells in the tail of the pancreas. □, control (Ctrl); ■, exendin-4 (Ex). *P < 0.05, scale bars = 100 μm. (A high-quality digital representation of this figure is available in the online issue.)