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. 2012 Apr 13;61(5):1250–1262. doi: 10.2337/db11-1109

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© 2012 by the American Diabetes Association.

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FIG. 7. — Exendin-4 actions on human pancreatic duct cells. A and B: Time-course experiments of CREB (A) and ERK1/2 (B) phosphorylation in HPDE cells treated with exendin-4 (10 nmol/L) for 0–30 min as indicated. GAPDH, glyceraldehyde-3-phosphate dehydrogenase. Representative examples of Western blot experiments are shown in the top panels and the corresponding analysis in the bottom panels. C and D: Effect of long-term (0–9 h) stimulation on cyclin D1 (C) and cyclin A (D) protein levels. Data are expressed as the mean ± SD density ratio of total CREB, ERK1/2 (A and B), as well as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (C and D) from 3 to 5 independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001 vs. untreated control value.