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. 2012 Apr 13;61(5):1051–1061. doi: 10.2337/db11-1180

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© 2012 by the American Diabetes Association.

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FIG. 2. — Loss of AMPK-α2 impairs the CR-induced insulin-sensitizing effect and increase of glucose uptake in skeletal muscle. A and B: After 8 weeks of AL or CR treatment, ITT assay showing that CR improved insulin sensitivity in aged 16–17 week WT mice (A) but not in age-matched AMPK-α2 knockout (α2KO) mice (B). C and D: GTT assay showing the glucose (C) and insulin (D) levels of WT and AMPK-α2^−/− mice. The insulin-sensitizing effect of CR was significantly reduced in AMPK-α2^−/− mice. E: Loss of AMPK-α2 abolished the CR-induced increase of uptake of a fluorescent deoxyglucose analog (2-NBDG) in fresh isolated skeletal muscle. *P < 0.05, **P < 0.01 vs. AL. n = 8 per group. RFU, relative fluorescence units.