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. 2012 Apr 13;61(5):1281–1290. doi: 10.2337/db11-1549

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© 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 6. — Peripheral blood monocyte subset distribution in type 1 diabetic patients and their at-risk relatives. The percentage of monocytes in each of the 4 monocyte subsets was determined by flow cytometry analysis of surface CD14 and CD16 expression in whole PB. A–D: PB monocyte subset distribution was determined for healthy control subjects (HC) (circles), long-standing type 1 diabetic patients (D, squares, >12 months after diagnosis), recent-onset type 1 diabetic patients within 3 months of diagnosis (D[Dx], triangles). PB monocyte subset distribution in healthy control subjects (filled shapes) and FDR (unfilled shapes) (E) is shown. Correlation between %CD14⁺/CD16⁺ monocytes and monocyte CX3CR1 surface expression (F) is shown. ***P < 0.0001; **P < 0.01; *P < 0.05.