FIG. 3.

β-Cell proliferation in pregnant PancMet KO mice. A–D: Representative photomicrographs of nonpregnant (NP) (A and B) and pregnant (C and D) (at GD15) wild-type (WT) and PancMet KO mouse pancreatic sections stained for insulin (green) and BrdU (red). Arrows indicate BrdU-positive β-cell nuclei. E: Quantification of the percentage of BrdU-positive β-cells in pregnant, PPD4, and nonpregnant wild-type (n = 4–8) and PancMet KO (n = 4–7) mice. Results are means ± SEM. *P < 0.05 vs. nonpregnant mice of corresponding genotype; ^P < 0.05 vs. wild type at the same GD or PPD4. (A high-quality digital representation of this figure is available in the online issue.)