Table 4. The literature-selected SNPs significant associations with AD, CRC or PCa, considering allelic and additive models.
| Allelic | Additive model | |||||||||
| dbSNP IDa | Region | Geneb | MA | G1 vs. G2 | OR (95% CI) | p-value | p-valuecor. | OR (95% CI) | p-value | p-valuecor. |
| rs1800894 | 1q32.1 | IL10 (promoter) | T | AD vs. N | 0.67 (0.47–0.96) | 2.77E-02 | 2.23E-01 | 0.58 (0.38–0.89) | 1.24E-02 | 1.24E-01 |
| AD vs. N (F) | 0.79 (0.5–1.25) | 3.15E-01 | 8.03E-01 | 0.53 (0.30–0.94) | 3.08E-02 | 3.19E-01 | ||||
| CRC vs. N (F) | 1.61 (1.09–2.39) | 1.67E-02 | 9.42E-02 | 1.6 (1.05–2.44) | 2.98E-02 | 1.48E-01 | ||||
| CRC vs. AD | 1.78 (1.21–2.64) | 3.28E-03 | 2.03E-02 | 2.1 (1.30–3.37) | 2.24E-03 | 2.61E-02 | ||||
| CRC vs. AD (F) | 2.04 (1.2–3.45) | 7.01E-03 | 1.15E-01 | 3.03 (1.58–5.81) | 8.51E-04 | 2.55E-02 | ||||
| rs373572 | 3p25.3 | RAD18 (exon) | C | CRC vs. AD (M) | 0.83 (0.67–1.02) | 7.02E-02 | 2.62E-01 | 0.78 (0.61–0.99) | 4.55E-02 | 2.44E-01 |
| rs822395 | 3q27.3 | ADIPOQ (intron) | C | CRC vs. N (F) | 1.2 (1.01–1.43) | 3.67E-02 | 1.65E-01 | 1.28 (1.05–1.55) | 1.28E-02 | 1.03E-01 |
| CRC vs. AD (F) | 1.3 (1.06–1.6) | 1.29E-02 | 1.15E-01 | 1.33 (1.05–1.69) | 1.70E-02 | 2.55E-01 | ||||
| rs2229992 | 5q21 | APC (exon) | T | CRC vs AD (M) | 1.26 (1.04–1.51) | 1.81E-02 | 2.05E-01 | 1.26 (1.00–1.59) | 4.75E-02 | 2.44E-01 |
| rs16892766 | 8q23.3 | EIF3H | C | CRC vs. N | 1.63 (1.34–1.97) | 6.27E-07 | 2.38E-05 | 1.45 (1.16–1.81) | 9.71E-04 | 1.65E-02 |
| CRC vs. N (F) | 1.76 (1.34–2.3) | 4.11E-05 | 1.48E-03 | 1.53 (1.12–2.09) | 7.13E-03 | 9.88E-02 | ||||
| CRC vs. N (M) | 1.5 (1.12–2.01) | 7.08E-03 | 6.37E-02 | 1.43 (1.01–2.01) | 4.26E-02 | 2.73E-01 | ||||
| CRC vs. AD | 1.34 (1.07–1.68) | 1.09E-02 | 4.73E-02 | 1.39 (1.07–1.82) | 1.48E-02 | 7.42E-02 | ||||
| rs6983267 | 8q24.21 | intergenic | T | AD vs. N | 0.84 (0.75–0.95) | 3.39E-03 | 5.76E-02 | 0.84 (0.74–0.96) | 1.14E-02 | 1.24E-01 |
| AD vs. N (F) | 0.81 (0.69–0.94) | 5.11E-03 | 8.94E-02 | 0.8 (0.68–0.95) | 1.28E-02 | 1.98E-01 | ||||
| PCa vs. N | 0.77 (0.65–0.91) | 2.07E-03 | 1.04E-02 | 0.75 (0.62–0.90) | 2.49E-03 | 1.87E-02 | ||||
| rs1447295 | 8q24.21 | intergenic | A | PCa vs. N | 1.53 (1.18–1.97) | 1.13E-03 | 8.49E-03 | 1.41 (1.06–1.86) | 1.73E-02 | 6.49E-02 |
| rs1057910 | 10q23.33 | CYP2C9 (exon) | C | CRC vs. N (F) | 1.51 (1.11–2.05) | 8.12E-03 | 5.85E-02 | 1.51 (1.07–2.13) | 1.97E-02 | 1.26E-01 |
| CRC vs. AD (F) | 1.54 (1.05–2.25) | 2.63E-02 | 1.49E-01 | 1.57 (1.02–2.41) | 3.96E-02 | 3.24E-01 | ||||
| rs7931342 | 11q13.2 | MYEOV | G | PCa vs. N | 1.25 (1.05–1.47) | 1.10E-02 | 4.13E-02 | 1.27 (1.05–1.53) | 1.30E-02 | 6.48E-02 |
| rs3802842 | 11q23.1 | intergenic | C | CRC vs. AD | 0.82 (0.7–0.95) | 9.90E-03 | 4.73E-02 | 0.82 (0.69–0.97) | 2.43E-02 | 1.06E-01 |
| CRC vs. AD (M) | 0.79 (0.64–0.97) | 2.56E-02 | 2.05E-01 | 0.77 (0.60–0.98) | 3.30E-02 | 2.44E-01 | ||||
| rs7136702 | 12q13.13 | LARP4 | T | CRC vs. AD (M) | 1.17 (0.96–1.44) | 1.22E-01 | 3.57E-01 | 1.31 (1.03–1.67) | 3.04E-02 | 2.44E-01 |
| rs696 | 14q13.2 | NFKBIA (intron) | T | CRC vs. N (F) | 1.17 (0.98–1.38) | 7.59E-02 | 2.73E-01 | 1.22 (1.02–1.47) | 3.24E-02 | 1.48E-01 |
| rs4779584 | 15q13.3 | intergenic | T | AD vs. N (M) | 1.24 (1.01–1.54) | 4.28E-02 | 3.53E-01 | 1.34 (1.05–1.70) | 1.86E-02 | 5.04E-01 |
| CRC vs. N (M) | 1.34 (1.1–1.63) | 3.66E-03 | 5.10E-02 | 1.37 (1.09–1.73) | 7.46E-03 | 9.03E-02 | ||||
| rs9929218 | 16q22.1 | CDH1 (intron) | A | AD vs. N | 0.88 (0.78–1) | 5.05E-02 | 2.23E-01 | 0.86 (0.75–1.00) | 4.39E-02 | 2.63E-01 |
| AD vs. N (M) | 0.84 (0.69–1.02) | 8.08E-02 | 5.33E-01 | 0.77 (0.60–0.98) | 3.48E-02 | 5.04E-01 | ||||
| rs1859962 | 17q24.3 | intergenic | T | PCa vs. N | 0.73 (0.62–0.87) | 4.20E-04 | 6.30E-03 | 0.73 (0.61–0.89) | 1.57E-03 | 1.87E-02 |
| rs4939827 | 18q21.1 | SMAD7 (intron) | C | AD vs. N | 0.81 (0.72–0.9) | 1.98E-04 | 6.71E-03 | 0.82 (0.72–0.94) | 3.86E-03 | 1.16E-01 |
| AD vs. N (F) | 0.72 (0.62–0.84) | 1.96E-05 | 6.85E-04 | 0.76 (0.64–0.90) | 1.54E-03 | 4.78E-02 | ||||
| CRC vs. N | 0.83 (0.74–0.94) | 1.87E-03 | 2.18E-02 | 0.85 (0.75–0.96) | 1.20E-02 | 1.01E-01 | ||||
| CRC vs. N (F) | 0.79 (0.67–0.94) | 7.19E-03 | 5.85E-02 | 0.78 (0.65–0.94) | 9.26E-03 | 9.88E-02 | ||||
| rs961253 | 20p12.3 | intergenic | A | CRC vs. AD (M) | 1.2 (0.98–1.46) | 7.50E-02 | 2.62E-01 | 1.33 (1.05–1.68) | 1.65E-02 | 2.44E-01 |
Bold denotes significant association (p-valuecor<0.05). MA; minor allele (+) strand, G1 vs. G2; compared groups of cases and controls, respectively, OR; odds ratio, CI; confidence interval, N; control, PCa; prostate cancer, AD; adenoma, CRC; colorectal cancer, F; female, M; male.
a
/SNP identifier based on NCBI SNP database;
b
/NCBI ID of genes localized in proximity to the SNPs of interest (source: HapMap).