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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Immunol. 2012 Mar 23;188(9):4432–4440. doi: 10.4049/jimmunol.1103656

Figure 5. Nucleic acid-sensing TLRs are necessary for optimal virus-specific antibody responses in a chronic viral infection.

Figure 5

WT, Mavs−/− and Unc93b13d/3d (3d) mice were infected with LCMV Arm (acute) or clone 13 (chronic) and LCMV-specific IgG antibody titers in sera were measured by ELISA. (A) Antibody titers were analyzed in Arm-infected mice at day 15, 30 and 45 following infection (n=4–5). (B) Antibody titers at days 15, 30 and 44 following infection with 2 ×105 PFU clone 13 were determined in the indicated mice (n=4–8). (C) Antibody titers at days 30, 45 and 60 p.i. in indicated mice infected with 2 ×106 PFU clone 13 (n=4–5). Data are representative of two or more independent experiments. Graphs show the mean as a line and each data point represents an individual mouse. *P < 0.05, **P < 0.01 and ***P < 0.001 (two-tailed unpaired Student’s t-test).