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. Author manuscript; available in PMC: 2013 Apr 20.
Published in final edited form as: ACS Chem Biol. 2012 Feb 15;7(4):770–779. doi: 10.1021/cb200536r

Figure 3. (a-b): Treatment of compound CR1166 down-regulates EGFR and IGF-1R expression in AsPC-1 and MDA-MB-231-WT cells.

Figure 3

Figure 3

a-b. Western blot analysis of the proteins obtained from control (a) AsPC-1 cells or (b) MDA-MB-231-WT cells and cells treated with different modified Myr-GIPC peptides at different doses (50 µM – 200µM) for 48 hours. As determined by Western blotting, myristoylated GIPC peptides, most notably CR1166, regulates EGFR and IGF-1R expression in (a) AsPC-1 cells and (b) MDA-MB-231-WT cells. DMSO indicates cells treated with DMSO (required for 200 µM peptides dissolved in DMSO).