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. 2012 Apr 20;7(4):e35313. doi: 10.1371/journal.pone.0035313

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Gong et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Hematoxylin and eosin stained sections (×200), in the precentral gyrus of the frontal lobe (A and B) and CA1 area of the hippocampus (C and D) at 24 h following ROSC, showed changes in damaged neurons, including an eosinophilic cytoplasm, loss of Nissl substance and nuclear pyknosis (arrows). The number of damaged neurons from hypothermic pigs (B and D) was markedly decreased when compared to normothermic pigs (A and C).