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. 2012 Apr 20;7(4):e34973. doi: 10.1371/journal.pone.0034973

Figure 4. Effects of lestaurtinib on the mRNA expression of the androgen receptor target genes.

Figure 4

Expression of androgen receptor target genes TMPRSS2, IGF1-R, NKX3.1, CXCR4, MAK, MAF, N4A1, GREB1 and FKBP5 measured by qRT-PCR in androgen (R1881) stimulated LNCaP prostate cancer cells are lowered by the treatment with lestaurtinib (final concentration 5 µM). The mRNA expression of the GAPDH gene was used as a control. Bars represent mean + SD (n = 5). P-value: ns  =  non significant; *  =  <0.05; **<0.01; ***<0.001.