Table 4.
Effect of ULEtOH on the concentration (ng/g tissue) of monoamines and their metabolites in the hypothalamus of mice brain.
Groups | Hypothalamus (ng/g tissue) | |||||
---|---|---|---|---|---|---|
NE | MHPG | DA | DOPAC | 5-HT | 5-HIAA | |
Normal | 162.87 ± 18.84 | 359.47 ± 42.85 | 673.24 ± 39.45 | 632.91 ± 31.21 | 82.70 ± 1.59 | 610.04 ± 52.00 |
Control versus FST | 82.12 ± 10.34# | 301.73 ± 33.83 | 368.95 ± 24.42## | 359.99 ± 20.43 | 27.61 ± 4.24### | 250.69 ± 51.46## |
Imipramine 10 mg/kg | 491.34 ± 17.78** | 750.59 ± 67.95** | 466.00 ± 49.59 | 498.45 ± 12.95 | 72.86 ± 5.06*** | 780.53 ± 78.00*** |
ULEtOH 0.125 g/kg | 86.59 ± 20.24 | 256.23 ± 28.26 | 311.62 ± 49.34 | 344.75 ± 46.98 | 37.00 ± 6.16 | 612.67 ± 65.72** |
ULEtOH 0.25 g/kg | 161.51 ± 11.41 | 357.50 ± 22.94 | 407.61 ± 23.02 | 564.04 ± 42.35 | 40.99 ± 3.46 | 633.35 ± 65.61** |
ULEtOH 0. 5 g/kg | 148.62 ± 13.21 | 501.39 ± 57.27 | 439.88 ± 51.01 | 585.68 ± 26.87 | 86.84 ± 11.23*** | 877.39 ± 75.70*** |
Value were the means ± SEM (n = 6). # P < 0.05, ## P < 0.01, ### P < 0.001 as compared with the Normal group.
**P < 0.01, ***P < 0.001 as compared with the control group (one-way ANOVA following by Bonferroni's test).