Table. Determinants of antibody response to HAV immunization.
| Label | Value | Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|---|---|
| HAV Antibody Response# | OR (95% CI)& | p-value | OR (95% CI)& | p-value | |||
| No (N=225) | Yes (N=148) | ||||||
| Hormonal Contraception | no HC | 205(91.1) | 132(89.2) | 0.66 | -ref- | ||
| Depo or OCP | 20(8.9) | 16(10.8) | -ref- | 1.3 (0.6, 2.6) | 0.54 | ||
| Age | Mean±SD | 41.6± 7.6 | 41.7± 8.2 | 1.24 (0.6, 2.5) | 0.95 | ||
| Race/Ethnicity* | White | 24 (11)$ | 29 (20) | 0.004 | |||
| Hispanic | 83 (37) | 31 (21) | |||||
| African-American | 112 (50) | 84 (57) | -ref- | ||||
| Other | 6 (3) | 4 (3) | 0.3 (0.2, 0.6) | ||||
| Exposure | Intravenous drug use | 45 (20) | 35 (24) | 0.6 (0.3, 1.1) | 0.30 | ||
| Heterosexual | 106 (47) | 70 (48) | 0.6 (0.1, 2.2) | ||||
| Transfusion | 8 (4) | 1 (1) | |||||
| No identified risk | 65 (29) | 41 (28) | -ref- | ||||
| Group | Prevalent case | 98 (44) | 61 (41) | 0.8 (0.5, 1.5) | 0.67 | ||
| Incident case | 127 (56) | 87 (59) | 0.2 (0.02, 1.4) | ||||
| HIV RNA* | <400 copies/ml | 78 (35) | 68 (46) | 0.8 (0.5, 1.5) | 0.03 | 1.7 (1.0, 2.6) | 0.04 |
| ≥400 copies/ml | 147 (65) | 80 (54) | -ref- | ||||
| HAART | No | 54 (24) | 27 (18) | -ref- | 0.20 | ||
| Yes | 171 (76) | 121 (82) | 1.1 (0.7, 1.7) | ||||
| CD4 cells/ìl* | Mean±SD | 450±250 | 519±281 | 0.02 | 1.1 (1.0, 1.2) | 0.04 | |
| CD8 cells/ìl | Mean±SD | 878±429 | 860±352 | 1.6 (1.0, 2.4) | 0.67 | ||
| Baseline HAV antibodies* | <20 mIU | 78 (35) | 84 (57) | -ref- | <0.001 | 2.9 (1.9,4.6) | <0.001 |
| ≥20 mIU | 147 (65) | 64 (43) | 0.7 (0.4, 1.2) | -ref- | |||
#
Antibody response was defined by a ≥2-fold increase between baseline and peak antibody concentrations or by conversion from <20 to ≥20 mIU/ml.
&
Odds ratio (95% confidence interval)
$
Number (%)
*
Indicates factors that were significantly associated with antibody response to HAV vaccine in the univariate analysis.
Bold-facing underscores factors that remained significant in the multivariate analysis, which considered all significant factors identified by the univariate screen (see statistical methods) in model selection and HC use.