Table 2.
Numbers of mice examined from each genotype for each of the physiological and histological analyses performed in the present study
| M1 | M3 | M5 | M2 | M4 | M2/M4 | |
|---|---|---|---|---|---|---|
| Thresholds (ABR/DPOAE) | +/+ = 26 | +/+ = 29 | +/+ = 22 | +/+ = 16 | +/+ = 16 | +/+ = 10 |
| −/− = 13 | −/− = 13 | −/− = 14 | −/− = 8 | −/− = 8 | −/− = 11 | |
| Efferent function | +/+ = 4 | +/+ = 8 | +/+ = 4 | +/+ = 5 | ||
| −/− = 5 | −/− = 10 | −/− = 3 | −/− = 6 | |||
| Temporary noise damage | +/+ = 4 | +/+ = 6 | +/+ = 6 | +/+ = 6 | +/+ = 6 | +/+ = 7 |
| −/− = 3 | −/− = 3 | −/− = 4 | −/− = 4 | −/− = 4 | −/− = 7 | |
| Permanent noise damage | +/+ = 4 | +/+ = 8 | +/+ = 8 | +/+ = 8 | +/+ = 8 | +/+ = 7 |
| −/− = 3 | −/− = 5 | −/− = 8 | −/− = 8 | −/− = 8 | −/− = 7 | |
| Cochlear histopathology | +/+ = 3 | +/+ = 3 | +/+ = 3 | +/+ = 2 | ||
| −/− = 5 | −/− = 3 | −/− = 3 | −/− = 2 |
Histopathology and efferent function were not evaluated in the M2 or M4 single nulls, once we determined that the double nulls (M2/M4) were normal by both these assays.