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. 2012 Apr 20;7(4):e34036. doi: 10.1371/journal.pone.0034036

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(A) Addition of Fru2,6-BP can terminate the oscillations (red), or at an intermediate level (green), make the oscillations faster and smaller. (B) The Fru6-P nullcline (black) is unaffected by Fru2,6-BP, but Fru2,6-BP pulls together the knees of the Fru1,6-BP nullcline (shown as solid blue, then green and then red lines as Fru2,6-BP is increased as in (A)), eventually stabilizing the equilibrium that exists at the intersection of the Fru6-P and Fru1,6-BP nullclines. The orbit of the oscillation with Fru2,6-BP = 0 is shown (blue dashed line) along with an arrow indicating the orientation of the orbit.