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. 2012 Apr 20;7(4):e34036. doi: 10.1371/journal.pone.0034036

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(A) Mitochondrial NADH oscillations occur due to oscillations in glycolysis. These are terminated when the ratio V_PFK2/V_PFK2, and thus the Fru2,6-BP level, is sufficiently large. (B) Slow Ca²⁺ oscillations are made faster and smaller by the addition of PFK2/FBPase2, with V_PFK2/V_PFK2 = 0.5. They are replaced by fast Ca²⁺ oscillations when V_PFK2/V_PFK2 = 2.