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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Mol Cancer Res. 2011 Dec 7;10(2):250–258. doi: 10.1158/1541-7786.MCR-11-0287

Figure 4. The PDZ-binding domain of E6 is necessary to activate β-catenin-responsive genes in adult dorsal skin.

Figure 4

(A) Relative mRNA expression of three Wnt signaling-responsive target genes (ccnd1, c-myc and birc5) that were evaluated by RT-qPCR. All of the samples were obtained as described in the methods section. (B) RT-PCR and Western blot of the c-Myc gene in non-injured skin from the indicated mice, and from wild type-injured skin (positive control). Note that only the entire E6 protein induces c-Myc protein in a manner that is similar to the wound stimulus.