Table 1.

Whole-genome sequencing and DNA sequence variant statistics

	LFS-MB1	LFS-MB2	LFS-MB3	LFS-MB4
Tumor bases sequenced	109 × 109	120 × 109	37 × 109	143 × 109
Paired normal tissue bases sequenced	116 × 109	125 × 109	17 × 109	114 × 109
Tumor physical coverage (span coverage)	43.5×	45.8×	77.8×	112.2×
Paired normal physical coverage	41.6×	51.6×	3.3×	49.5×
Tumor sequencing coverage	30.8×	34.6×	8.9×*	38.5×
Paired normal sequencing coverage	31.4×	36.7×	4.6×*	34.4×
Total somatic mutations (whole genome)	3,716	3,053	-	2,494
Non-silent coding mutations (val./tested)	24 (20/21)	22 (19/20)	18(−/−)*	11 (8/10)
Mutation rate per Mb	1.29	1.06	-	0.88

^*In addition to whole-genome sequencing, whole-exome data was generated at 39× (tumor) and 37× (paired normal) coverage in this case.

‘−’, not assessed; val., validated.